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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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34 hot topic(s) found with the query "Psychiatric disorders"

New and emerging approaches to treat psychiatric disorders.
Katherine W Scangos et al. Nature medicine 2023 2 (Posted: Feb 17, 2023 7AM)

Here we review new and emerging treatment approaches, with a particular emphasis on the revolutionary potential of brain-circuit-based interventions for precision psychiatry. Limitations of circuit models, challenges of bringing precision therapeutics to market and the crucial advances needed to overcome these obstacles are presented.

Research priorities in psychiatric genetic counselling: how to talk to children and adolescents about genetics and psychiatric disorders
J Mundy et al, EJHG, December 21, 2022 (Posted: Dec 21, 2022 8AM)

Psychiatric genetic counselling is conceptually identical to genetic counselling for other types of disorders and its efficacy for adults diagnosed with psychiatric disorders and their family members has been documented [4]. We are now entering an era in which genetic information is likely to become far more available as it is gradually integrated into healthcare. Thus, how to effectively communicate complex genetic risk information is of high research priority.

Shared mechanisms across the major psychiatric and neurodegenerative diseases
TS Wingo et al, Nat Comm, July 26, 2022 (Posted: Jul 26, 2022 7AM)

Using 25 GWAS results and LD score regression, we find eight significant genetic correlations between psychiatric and neurodegenerative diseases. We integrate the GWAS results with human brain transcriptomes (n?=?888) and proteomes (n?=?722) to identify cis- and trans- transcripts and proteins that are consistent with a pleiotropic or causal role in each disease, referred to as causal proteins for brevity. Within each disease group, we find many distinct and shared causal proteins. Remarkably, 30% (13 of 42) of the neurodegenerative disease causal proteins are shared with psychiatric disorders.

COVID-19: a challenge and an opportunity.
Renieri Alessandra et al. European journal of human genetics : EJHG 2022 7 (Posted: Jul 18, 2022 10AM)

COVID-19 is the first disease in which environmental factors are well defined. Heritability (h2) as calculated by gV/gV+aV is very high in COVID-19, similarly to psychiatric disorders. While media are taking care mainly of the viral genome, the host genome is the real discriminant between severe COVID-19 and asymptomatic SARS-CoV-2 infection. Therefore, while COVID-19 is representing a challenge for the health systems and society, it is the first real opportunity to move forward on understanding mechanisms and new rules useful in clinical practice of complex disorders,

miRNAs as potential diagnostic biomarkers and pharmacogenomic indicators in psychiatric disorders.
Tsermpini Evangelia Eirini et al. The pharmacogenomics journal 2022 6 (Posted: Jun 28, 2022 7AM)

We provide herein a detailed overview of circulating miRNAs and their expression profiles as biomarkers in schizophrenia, bipolar disorder and major depressive disorder and their role in response to specific treatments. Bioinformatics analysis of miR-34a, miR-106, miR-134 and miR-132, which are common among SZ, BD and MDD patients, showed brain enrichment and involvement in the modulation of critical signaling pathways, which are often deregulated in psychiatric disorders. We propose that specific miRNAs support accurate diagnosis and effective precision treatment of psychiatric disorders.

Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis.
Nikolova Viktoriya L et al. JAMA psychiatry 2021 9 (Posted: Sep 18, 2021 11AM)

This systematic review and meta-analysis found that gut microbiota perturbations were associated with a transdiagnostic pattern with a depletion of certain anti-inflammatory butyrate-producing bacteria and an enrichment of pro-inflammatory bacteria in patients with depression, bipolar disorder, schizophrenia, and anxiety.

Genetic predisposition to psychiatric disorders and risk of COVID-19
W Chen et al, MEDRXIV, February 25, 2021 (Posted: Feb 26, 2021 8AM)

Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status.
Agerbo Esben et al. JAMA psychiatry 2021 Jan (Posted: Jan 14, 2021 9AM)

In this case-cohort study of 17?098 patients with depression, the absolute risk of depression by the age of 30 years differed substantially depending on an individual’s combination of risk factors, ranging from 1.0% among male individuals with high socioeconomic status in the bottom 2% of the polygenic risk score distribution to 23.7% among female individuals in the top 2% of PRS with a parental history of psychiatric disorders.

Advancing digital health: FDA innovation during COVID-19
K Kadakia et al, NPJ Digital Medicine, December 2020 (Posted: Dec 21, 2020 7AM)

The U.S. Food and Drug Administration (FDA) has issued a number of temporary policies to support digital health innovation during the pandemic, such as guidance documents to expand the use of digital therapeutics for psychiatric disorders and medical devices for remote patient monitoring.

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
F Till et al, Molecular Psychiatry, November 11, 2019 (Posted: Nov 12, 2019 8AM)

Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map.
Austin Jehannine C et al. Cold Spring Harbor perspectives in medicine 2019 Sep (Posted: Sep 18, 2019 9AM)

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems.
Zheutlin Amanda B et al. The American journal of psychiatry 2019 Aug appiajp201918091085 (Posted: Aug 19, 2019 8AM)

The study demonstrates that an available measure of poly genetic risk for schizophrenia is robustly associated with schizophrenia in health care settings and has pleiotropic effects on related psychiatric disorders as well as other medical syndromes.

Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders.
Zhou Yi et al. Journal of neuroscience research 2018 Dec (Posted: Mar 18, 2019 5PM)

Novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide.
RJ Strawbridge et al, BIORXIV, October 25, 2018 (Posted: Oct 26, 2018 11AM)

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores
N Mullins et al, BioRXIV Preprints, September 2018 (Posted: Sep 16, 2018 2PM)

National-scale precision medicine for psychiatric disorders in Sweden.
Bergen Sarah E et al. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2017 Jul (Posted: Jul 12, 2017 11AM)

The Efficacy of Genetic Counseling for Psychiatric Disorders: a Meta-Analysis.
Moldovan Ramona et al. Journal of genetic counseling 2017 Jun (Posted: Jun 21, 2017 8AM)

Chromosomal microarray testing in adults with intellectual disability presenting with comorbid psychiatric disorders
K Wolfe et al, Eur J Hum Genetics, September 22, 2016 (Posted: Sep 23, 2016 8AM)

Prenatal genetic counseling for psychiatric disorders.
Inglis Angela et al. Prenatal diagnosis 2016 Jul (Posted: Aug 03, 2016 9AM)

Pharmacogenetics of alcohol use disorders and comorbid psychiatric disorders.
Helton Sarah G et al. Psychiatry research 2015 Dec (2) 121-9 (Posted: Apr 06, 2016 11AM)

Psychiatric disorders in Ehlers-Danlos syndrome are frequent, diverse and strongly associated with pain.
Hershenfeld Samantha Aliza et al. Rheumatology international 2015 Oct (Posted: Feb 15, 2016 2PM)

Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders.
Jawahar Magdalene C et al. Clinical epigenetics 122 (Posted: Nov 23, 2015 9AM)

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders.
Kelly John R et al. Frontiers in cellular neuroscience 2015 392 (Posted: Nov 06, 2015 9AM)

A Naturalistic Study of the Effectiveness of Pharmacogenetic Testing to Guide Treatment in Psychiatric Patients With Mood and Anxiety Disorders.
Brennan Francis X et al. The primary care companion for CNS disorders 2015 17(2) (Posted: Oct 14, 2015 11AM)

Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population.
Pettersson E et al. Molecular psychiatry 2015 Aug (Posted: Oct 13, 2015 1PM)

More harm than good? Use of genetic mental health tests has grown rapidly. But evidence they work is scant. (+documentation)
B Daley, NECIR, Health and Safety, October 3, 2015 (Posted: Oct 05, 2015 11AM)

Genetic tests for psychiatric drugs spur hope, doubts
B Daly, Boston Glove, October 3, 2015 (Posted: Oct 05, 2015 9AM)

Genetics and genomics of psychiatric disease
DH Gesschwind et al. Science, September 25, 2015 (Posted: Sep 28, 2015 4PM)

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Lindqvist Daniel et al. Neurosci Biobehav Rev 2015 May 18. 333-364 (Posted: Jul 13, 2015 11AM)

Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome.
Hirschtritt Matthew E et al. JAMA Psychiatry 2015 Apr (4) 325-33 (Posted: Jun 02, 2015 9AM)

Optogenetics and the Circuit Dynamics of Psychiatric Disease
Deisseroth K, et al. JAMA 2015 May 14 (Posted: May 14, 2015 11AM)

Brain disorders? Precisely.
Insel Thomas R et al. Science 2015 May 1. (6234) 499-500 (Posted: May 02, 2015 3PM)

Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis.
Agerbo Esben et al. JAMA Psychiatry 2015 Apr 1. (Posted: Apr 05, 2015 8AM)

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
Mullins Niamh et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2014 Jul (5) 428-37 (Posted: Feb 28, 2015 8PM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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